Recombinant Human Interleukin‐11 Has Anti‐inflammatory Actions Yet Does Not Exacerbate SystemicListeriaInfection
نویسندگان
چکیده
منابع مشابه
Recombinant human interleukin-11 has anti-inflammatory actions yet does not exacerbate systemic Listeria infection.
To determine whether recombinant human (rh) interleukin (IL)-11 disrupts the clearance of microbial pathogens, mice were challenged with Listeria monocytogenes after receiving high-dose rhIL-11, anti-tumor necrosis factor (TNF) monoclonal antibody (MAb), anti-IL-11 MAb, or saline control. The LD50 was not affected by rhIL-11 but was 10-fold lower in the anti-TNF MAb group (P<.001). Plasma IL-6,...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2000
ISSN: 0022-1899,1537-6613
DOI: 10.1086/315247